This chapter deals with the issue of denoising DCE-MR images. Noise in MRI may mask fine details in the image and diminish its effective resolution, making both manual and automatic analysis of the image more complicated and less reliable. This chapter introduces the motivation for denoising methods for MRI. Also, the chapter presents a novel denoising method. The method is called Dynamic Non-Local Means (DNLM) and is designed specifically for the denoising of DCE-MRI. The DNLM is a variation of the Non-Local Means algorithm (NLM)